Active factor (INN – International Non-proprietary Name)

Cephazolin (as sodium salt)

 

Code ATC: J01DA04

 

Pharmacotherapeutic group

Antibiotic (group of cephalosporins)

 

Pharmacological properties

The drug is one of major first-generation cephalosporin antibiotics.
It has a broad spectrum of antimicrobial action, it acts bactericidal. The mechanism of action is associated with inhibition of biosynthesis of cell wall of microorganisms. It is active against gram-positive and gram-negative bacteria, including staphylococci, synthesizing and not synthesizing penicillinase, on hemolytic streptococci, pneumococci, Salmonella, Shigella, some Proteus, microbes of group of Klebsiella, diphtheria bacillus, anthrax, gonococci, meningococci, it is also active against spirochetes, and Leptospira.
The drug is ineffective against Staphylocci, resistant to methicillin, Pseudomonas aeruginosa, indole-positive strains of Proteus, Mycobacterium tuberculosis, anaerobic microorganisms, it has no effect on Rickettsia, viruses, fungi and protozoa.

 

Indications for use

Treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the drug, including diseases of upper and lower respiratory tract, urinary and biliary tracts, pelvic organs, skin and soft tissues, bones and joints, endocarditis, sepsis, peritonitis, otitis media, osteomyelitis, mastitis, wound, burn and post-operative infections, syphilis and gonorrhea. In addition, the drug is used for prevention of surgical infections in pre- and post-operative periods.

 

Pharmaceutical form

Powder of 0.5 or 1.0 g in vials.

 

Cephazolin sodium salt

Hepatoprotectors
Antibiotics
Local anaesthetic drugs
Nootropic drugs
Antihypertensive drugs
Drugs for a parenteral food
Medicines applied at poisonings and intoxications
Medicines for metabolic processes correction
Medicines for peripheric blood circulation
Mineral drugs, microcells
Salt solutions
Analgesic and antispasmodic drugs
Nonsteroidal anti-inflammatory drugs
Haemostatics