Code ATC: N01ВА02
Local anesthetic drugs
Local anesthetic agent with a weak anesthetic activity and large breadth of safety. Blocks voltage-dependent sodium channels, prevents generation of impulses in sensory nerve endings and propagation of impulses by nerve fibers. Inhibits propagation of not only painful impulses, but also impulses of other modalities. Firstly, under the influence of drug, cold sense is lost, and then consequently sense of warm, pain and pressure disappears. In resorptive effect, the drug has a depressant effect on central nervous system, inhibits spasms of smooth muscles, inhibits release of acetylcholine from presynaptic terminals and thus, it has some ganglion blocking action, in large doses it may disturb neuromuscular conductibility. The drug has also hypotensive action and dysrhythmic activity (reduces excitability and automaticity, deteriorates conductivity). Duration of action in infiltration anesthesia is half an hour or an hour. Duration of action in other types of anesthesia depends on concentration of the drug, its combination with solution of adrenaline and it comprises from half an hour to an hour and a half in average.
Infiltration, intraosseous anesthesia; paranephric and vagosympathetic blocks; freezing injuries (before reactive period); essential hypertension, late toxicoses with hypertonic syndrome, phantom pains, gastric and duodenal ulcer, itching, dermatitis, eczema, keratitis, iridocyclitis, and glaucoma. It is also used for dilution of penicillin.
0.5% solution for injection in ampoules of 5 ml and 10 ml.